Dynamo mapping vector field of single cells
WebDynamo: Mapping Transcriptomic Vector Fields of Single Cells. Inclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction, potential landscape mapping, … WebLeveraging the least-action-path method, dynamo accurately predicts drivers of numerous hematopoietic transitions. Finally, in silico perturbations predict cell-fate diversions induced by gene perturbations. Dynamo, thus, represents an important step in advancing quantitative and predictive theories of cell-state transitions.
Dynamo mapping vector field of single cells
Did you know?
WebFeb 1, 2024 · Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, however, requires ... WebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - dynamo-release-Mapping-Vector-Field-of-...
WebJul 9, 2024 · Abstract. Single-cell RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, however ... WebSingle-cell RNA-seq pseudotime estimation algorithms. Single cells, many algorithms. The goal of this page is to catalog the many algorithms that estimate pseudotimes for cells based on their gene expression levels. This problem is also referred to as single-cell trajectory inference or ordering.
WebDeciphering gene regulation through vector fields analysis in pancreatic endocrinogenesis¶. cellDancer could be integrated into downstream analysis, such as dynamo proposed by Qiu et al.. In this tutorial, the output of cellDancer (PancreaticEndocrinogenesis_cellDancer_estimation.csv) in pancreatic … WebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - GitHub - KBRI-Biology-Experiment-Comput...
WebDynamo: Mapping Vector Field of Single Cells¶ Understanding how gene expression in single cells progress over time is vital for revealing the mechanisms governing cell fate …
WebMar 31, 2024 · Wagner, D. E. et al. Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science 360, ... Qiu, X. et al. Mapping vector field of single cells. how to reverse arraylist in javascriptWebFeb 2, 2024 · Our analytical framework, dynamo, consists of four integral stages: 1) estimation of genome-wide kinetic rate constants and velocity vectors, 2) reconstruction of single-cell vector field functions with the resultant cell state and velocity samples, 3) in-depth analyses leveraging various differential geometry analyses, and 4) predictions of ... how to reverse array in pythonhttp://dynamo-readthedocs.readthedocs.io/ how to reverse a spellWeb•Vector fields reveal the timing and mechanisms of human hematopoiesis •Dynamo allows cell-state transition path and in silico perturbation predictions . Summary. Single-cell … north east regional leagueWebJul 9, 2024 · Single-cell RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these … how to reverse arraylistWebFeb 1, 2024 · Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, howev how to reverse a return delivery in sapWebJul 9, 2024 · Here, we introduce dynamo , an analytical framework that reconciles intrinsic splicing and labeling kinetics to estimate absolute RNA velocities, reconstructs velocity vector fields that predict future cell fates, and finally employs differential geometry analyses to elucidate the underlying regulatory networks. northeast regional leonberger club