Irf2bp2 cancer

WebIRF2BP2 INFORMATION. Proteini. Full gene name according to HGNC. Interferon regulatory factor 2 binding protein 2. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. IRF2BP2 (IRF-2BP2) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). WebSep 20, 2024 · IRF2BP2 stabilized VGLL4 protein and repressed tumor progression via the inactivation of YAP-TEAD4 complex in liver cancer (41). In contrast, IRF2BP2 repressed …

IRF2BP2 - My Cancer Genome

WebJul 20, 2015 · IRF2BP2 is a cofactor modulating IRF2 and myocyte enhancer factor 2 (MEF2), transcription factors important for innate immunity and gene expression in macrophages. 8 – 12 Exposure of macrophages to bacterial lipopolysaccharide activates the M1 inflammatory phenotype, whereas exposure to interleukin (IL)-4 favors the M2 anti … WebJul 31, 2024 · Overall, cases 12 (harboring IRF2BP2-NTRK1 ), 13 ( PPL- NTRK1 ), and 25 ( ETV6-NTRK3) were morphologically similar, composed of lobules of partially fused papillae with scattered glomeruloid... inalandscape.org https://nhukltd.com

The Tumor Suppressor Interferon Regulatory Factor 2 Binding

WebMay 19, 2016 · The IRF2BP2–CDX-1 fusion gene has been reported in mesenchymal chondrosarcoma, 16 and there is one previous report of IRF2BP2–RARA in APL. 10 Yin et al. 10 reported a case of APL with IRF2BP2–RARA that involved exon 2 of IRF2BP2 and intron 2 of RARA, with breakpoints at positions 1687 bp in IRF2BP2 and 41620 bp in RARA. The … WebSep 20, 2024 · In this study, we uncovered the clinical significance of IRF2BP2 in suppressing hepatocellular carcinogenesis. We showed that IRF2BP2, a direct target repressed by the Yes-associated protein … WebIRF2BP2 is involved in 1 fusion, with the following gene: CDX1 (1 mutation in 4 samples) Drug sensitivity data Mutations in IRF2BP2 are associated with altered sensitivity to the following 10 drugs: Dactolisib Docetaxel SN-38 Show all See all drug sensitivity data for IRF2BP2. External links inch memorials michigan

IRF2BP2 interferon regulatory factor 2 binding protein 2 - NIH Genetic

Category:The Tumor Suppressor Interferon Regulatory Factor 2 …

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Irf2bp2 cancer

Special Issue "The Regulation of JAKs in Health and in Disease"

WebApr 1, 2024 · Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) binds to various RNA transcripts and promotes cancer progression, although little is known regarding its regulation. Here we show IGF2BP2 is a substrate of the deacetylase and tumor suppressor sirtuin 1 (SIRT1) and regulates the expression of the vacuolar ATPase subunit ATP6V1A. WebApr 8, 2024 · The researchers discovered Richter syndrome-specific somatic driver mutations in genes including IRF2BP2, SRSF1, B2M, DNMT3A, and CCND3. They also found recurrent copy-number alterations beyond del(9p21)(CDKN2A/B), whole-genome duplication and chromothripsis, which they confirmed in 45 independent Richter syndrome cases and …

Irf2bp2 cancer

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WebInterferon regulatory factor 2 binding protein 2 (IRF2BP2) was originally identified as a transcriptional corepressor. However, the association between IRF2BP2 and the Hippo … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆

WebApr 25, 2024 · The IRF2BP2 (IFN regulatory factor 2 binding protein 2) protein was identified as a nuclear protein that interacts with IFN regulatory factor 2 (IRF-2) and is an IRF-2 … WebJun 15, 2024 · Recently, interferon regulatory protein 2 binding protein 2 ( IRF2BP2) emerged as a new RARA partner and was studied by next-generation RNA-sequencing analysis. IRF2BP2 has also been involved in other solid tumors [ 2, 3, 4 ]. Fig. 1 A Wright-Giemsa staining of abnormal promyelocytes at diagnosis. B Alpha naphthol acetate …

WebNational Center for Biotechnology Information WebApr 25, 2024 · Additionally, IRF2BP2 may be involved in cancer development. Finally, it has been recently reported that IRF2BP2 may play a role in macrophage regulation and lymphocyte activation, highlighting ...

WebMar 17, 2024 · The data show that IRF2BP2 is a novel target gene repressed by the YAP-TEAD transcriptional complex, and exhibits potent antitumor activity by inhibiting YAP activity. The researchers identify that IRF2BP2 interacts with VGLL4 and stabilizes the protein level of VGLL4, which leads to synergistic inhibition toward YAP.

WebSep 25, 2015 · In a recent issue of Circulation Research, Chen et al report that IRF 2–binding protein 2 (IRF2BP2) is a novel regulator of macrophage inflammation and lipid homeostasis that acts by maintaining anti-inflammatory transcription factor Krüppel-like factor 2 (KLF2) expression, therefore reducing susceptibility to atherosclerosis 6 ( Figure 2 ). inch meter converterWebJan 1, 2024 · For example, IRF2BP2 is confirmed to be upregulated in gastric cancer, and its deficiency impedes cell proliferation and epithelial-mesenchymal transition. 42 IRF2BP2 represses liver cancer progression via stabilizing VGLL4 and further enhancing VGLL4’s inhibitory effects on Hippo pathway. 43 In our study, we discovered that IRF2BP2 might … inalatherWebApr 25, 2024 · Abstract. The IRF2BP2 (IFN regulatory factor 2 binding protein 2) protein was identified as a nuclear protein that interacts with IFN regulatory factor 2 (IRF-2 inch metric decimal equivalents chart pdfWebMar 21, 2024 · IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene. Diseases associated with IRF2BP2 include Immunodeficiency, Common … inch memory foam topperWebIRF2BP2_ENST00000366610 Sequences You can see various sequences for this gene: cDNA (ENST00000366609.3) Protein (IRF2BP2) Transcript and protein aligned … inch metre hesaplamaWebJul 30, 2024 · The levels of the co-transcriptional regulator IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein-2) decrease with T cell activation and, when ectopically expressed, it reduces T cell proliferation. To further characterize the function of IRF2BP2 in T cell responses in vivo, we generated a conditional transgenic knock-in mouse that … inch memory foamWeb癌症免疫疗法是生物医学界目前最热门的领域之一。近日，发表在《科学》杂志上的一项研究中，科学家们发现了一种参与肿瘤免疫逃逸行为的关键蛋白，它与“赫赫有名”的PD-L1蛋白的表达密切相关。这一名为Cdk5的关键蛋白及其相关信号通路有望成为免疫疗法的新靶点。 inalatore tabi thermae